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CORONAVIRUS CAN BE PREVENTED - VITAMIN D SOLUTION
536,136 views•Mar 15, 2020

Renu Mahtani
10K subscribers
One of the well explored effects of vitamin D is the regulation of the immune system. Vitamin D deficiency is now a global pandemic. Correction of any deficiency is an obligation and a necessity. It will not cause side effects since one is just normalizing a biological parameter. Its time to become D +ve....Its immuno-modulatory mechanisms to prevent the difficult to treat respiratory infections are many:
1. upregulation of innate and adaptive immunity
2. expression and secretion of immuno-peptides cathelicidins and defensins that boost body's defense mechanisms
3. protection against LPS induced acute lung injury
4. suppression of cytokine storm by downregulating the production of Renin and upregulation of the protective ACE2

Sun exposure along may not suffice as most of us are not ready for it in our urban lifestyle - the recommended healthy sunexposure is - 15 to 20 mins with 70% body exposed between 10 am to 2 pm. There are other reasons that limit vitamin D in the body - magnesium deficiency, pollution and toxins that do not allow the liver and kidneys to participate adequately in vit D activation, VDR or vitamin D receptor polymorphisms....

The information is for educative purpose and there are no commercial motives for any brand or any service. Humanity is going through a health crisis and this is a gesture for caring for the health of society as such.

References:
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Vitamin D status in Indian population: Major health concern. Yadav, Krishnat. World Journal of Pharmaceutical Research.(2015). 5. 362-378.

Systematic Review on Vitamin D Level in Apparently Healthy Indian Population and Analysis of Its Associated Factors. Sandhiya Selvarajan, et al. Indian J Endocr Metab 2017;21:765-75.

Acute Respiratory Tract Infection and 25-Hydroxyvitamin D Concentration: A Systematic Review and Meta-Analysis. Pham H, Rahman A, et al. Int J Environ Res Public Health. 2019 Aug 21;16(17).

Vitamin D and Critical Illness Outcomes. Christopher, Kenneth B. 2016. Current Opinion in Critical Care 22 (4): 332–38.

Low Vitamin D Status Occurs in 90% of Patients with ARDS and Is Associated with Longer Duration of Mechanical Ventilation. Ednan K. Bajwa, et al. American Journal of Respiratory & Critical Care Medicine 2016;193:A1846.

Vitamin D Supplementation Could Prevent and Treat Influenza, Coronavirus, and Pneumonia Infections. Grant, W.B.; Lahore, H.; McDonnell, S.L.; Baggerly, C.A.; French, C.B.; Aliano, J.L.; Bhattoa, H.P. Preprints 2020, 2020030235

Vitamin D deficiency:a factor in COVID-19, progression, severity and mortality?An urgent call for research. Brown R, Sarkar A. MitoFit Preprint Arch (2020) doi:10.26124/mitofit:200001.

Preventing a Covid-19 Pandemic. Watkins, John. 2020. BMJ 2020;368:m810

The Role of Vitamin D in Suppressing Cytokine Storm in COVID-19 Patients and Associated Mortality. Ali Daneshkhah, et al. medRxiv 2020.04.08.20058578;

Effect of Cholecalciferol Supplementation on Vitamin D Status and Cathelicidin Levels in Sepsis: A Randomized, Placebo-Controlled Trial. Quraishi SA, et al. Crit Care Med. 2015;43(9):1928–1937.

A 21st century evaluation of the safety of oral vitamin D. Glade MJ. Nutrition. 2012;28(4):344–356.

High-dose oral vitamin D3 supplementation in the elderly (RCT). Bacon CJ, et al. Osteoporos Int. 2009 Aug;20(8):1407-15.

Daily oral dosing of vitamin D3 using 5000 TO 50,000 international units a day in long-term hospitalized patients: Insights from a seven year experience. McCullough PJ, J. J Steroid Biochem Mol Biol. 2019 May;189:228-239.

High dose vitamin D administration in ventilated intensive care unit patients: A pilot double blind randomized controlled trial. Jenny E. Han, et al. Journal of Clinical & Translational Endocrinology 4 (2016) 59–65

Short-term effects of high-dose oral vitamin D3 in critically ill vitamin D deficient patients: a randomized, double-blind, placebo-controlled pilot study. Amrein et al. Critical Care 2011, 15:R104, http://ccforum.com/content/15/2/R104

Evaluation of vitamin D repletion regimens to correct vitamin D status in adults. Pepper KJ, Judd SE, Nanes MS, Tangpricha V. Endocr Pract. 2009;15(2):95–103.

Effect of a Single Oral Dose of 600,000 IU of Cholecalciferol on Serum Calciotropic Hormones in Young Subjects with Vitamin D Deficiency: A Prospective Intervention Study. Cristia na Cipriani, et al. JOCM, 95, 10, 1 2010, 4771–4777

Effect of oral versus intramuscular Vitamin D replacement in apparently healthy adults with Vitamin D deficiency. Nitin Gupta, Khalid J.et al. Indian J Endocrinol Metab. 2017, 21(1): 131–136.

28. Results of daily oral dosing with up to 60,000 international units (iu) of vitamin D3 for 2 to 6 years in 3 adult males. McCullough P, Amend J. J Steroid Biochem Mol Biol. 2017 Oct; 173:308-312.

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God Bless