Algernon Pharmaceuticals Inc (AGNPF)

[medchem]

Some Science

1. Pre-clinical research: check out your BioPub interviews. These are quick and explain Algernon's plan of action in a concise and clear way. They make the science easy to understand. They discuss the positive data from animal studies that shows our drugs generated positive signal and treated the disease of interest. One aspect of our drug pipeline is for idiopathic pulmonary fibrosis and chronic cough. Our lead outperforms the best drug big pharma has to offer.

Algernon Pharmaceuticals’ NP-120 (Ifenprodil) Outperforms Merck’s Phase 3 Drug MK-7264 (Gefapixant) in an Acute Cough Study by 110%

Ifenprodil works for severe acute lung injury and acute respiratory distress syndrome (ARDS) which is what is killing people who get COVID-19, novel coronavirus.

We are skipping preclinical testing because previous studies have shown are drug is safe. In animal models it greatly reduced mortality from severe viral respiratory disease... just like what we are expecting with COVID. Now we have plans for studying in South Korea, Autralia, and Canada. All in humans via Phase 2 trials.

2. Safety testing usually cost hundreds of millions. We are using repurposed drugs. We have patents protecting Ifenprodil for respiratory diseases - and it's sister drug. We are saving the hundreds of millions by using the safe drugs. We are doing some FDA-registered clinical trial testing in the USA. We will show it's safe for injection by IV, as well as oral long acting.

3. Clinical trials: We have NOVOTECH which is a certified CRO which is going to be running our trials. We have funding. We have drug ready to go. We are also producing more drug using a certified American chemistry company. We have NOVOTECH investing there own money in Algernon. FDA and medical regulatory authorities in Australia and South Korea and Canada will fast track ifenprofil for COVID-19 related use. Ethics can get approved in days to weeks. Maybe by next week for the South Korea study.

4. Why it works:

Coronaviruses may invade the nervous system and we have a drug that protects the neurons. COVID-19 may invade neurons causing respiratory failure. Coronaviruses invade the nervous system.

Here is proof:

PROOF Coronaviruses infect neurons

Our drug protects them by working on the NMDA receptor.

NMDA receptor

The nervous system invasion by the virus can cause a lot of inflammatory mediators (aka inflammation) to be release and that causes the NMDA receptor to cause neuron injury. This is important because our drug blocks that. Already doctors are publishing work showing covid-19 hurts the nervous system.

And like I said before, here's how our drug works:

Coronavirus infection induces increased production of proinflammatory cytokines and neuronal degeneration as a consequence of glutamate excitotoxicity. In physiological conditions, glutamate is mainly synthesized by neurons and released in the synaptic cleft as the primary excitatory neurotransmitter of the CNS that activates the ligand-dependant receptor AMPAr, which allows the entry of sodium ions and the passage of the nerve impulse in the post-synaptic neuron, leading to activation of the NMDA receptor (N-methyl-D-aspartate receptor) that allows the entry of calcium ions. During infection of neurons by coronavirus, microglial cells detect the presence of virus and produce pro-inflammatory cytokines (TNF-alpha, IL-1 beta and IL-6) that down-regulate the astrocytic receptor GLT-1 (glutamate transporter 1) and prevent the efficient recapture of glutamate. This situation disturbs the regulation of glutamate homeostasis and theexcess of this neurotransmitter in the synaptic cleft leads to excitotoxicity associated with a massive entry of calcium which eventually leads to degeneration of and death of neuronal cells.

This is why NMDA ANTAGONIST IFENPRODIL is going to be helpful for saving neurons! Ifenprodil works on the NMDA receptor on neurons.


And SARS-COV-2 aka COVID-19 hurts the neurons.

This study shows NMDA receptor plays a role in neuronal cell death.

So Ifenprodil may actually help keep the neurons alive. It might help people from failing to breath.