Premier Biomedical Inc (BIEI)

[Neen1]

Another good article on BIEI extracorporeal use in Covid-19

https://www.baxter.com/perspectives/healthcare-insights/confronting-coronavirus-managing-severe-cases-covid-19

"We may consider some other extracorporeal therapies, especially in the context of removal of inflammatory mediators. All of these options are what we call today ECOS, or extracorporeal organ support. Clinicians should be thinking about how to use ECOS in the best possible way to treat these patients. We need to have the technology available and we need to use this technology appropriately.

Q: What role do inflammatory mediators, including cytokines, have in treating patients with COVID-19?

A: What we know is that this disease causes an overwhelming inflammatory response in the body and this results in immunosuppression. It seems like after one week we may be able to identify those patients who will improve and those who will develop severe immunosuppression. Severe immunosuppression is likely to lead to severe infections and possible mortality. There is a case to be made to try to reduce that inflammatory reaction, because we know that the immunosuppressive phase is actually induced by the previously pro-inflammatory state. Also, giving corticosteroids is probably not a good idea because you do not want to give a therapeutic medication that may reduce the host response in the following days, and that is something to worry about. I don’t think there is any place for anti-inflammatory agents in these patients."