Entremed (ENMD)

[C_Peptide]

Re: Panzem coated stents.

A trial of Panzem coated stents is long overdue. J&J's corporate eyes should be lighting up with $$ at the prospect of owning them in partnership with EntreMed.

The problem with bare metal stents is that they stimulate a hypertrophic healing response that promotes restenosis of the vessel. The problem with the chemo-coated stents is that they are too good at suppressing healing, which prevents the formation of a normal endothelial lining, without which late thrombosis develops. A 2ME2 coated stent, using a less-toxic inhibitor of smooth muscle hyperproliferation, seems like a potential happy medium that deserves testing, even though the road to a product will be a very long one.

Best Regards,
C-Peptide