Generex Biotechnology Corp. (fka GNBTQ)

[WeeZuhl]

wee zuhl, docj or anyone else...

Was told that they are finding COVID-19 does not just do respiratory damage

COVID-19 spike protein requires cleavage by human furin enzyme, which is fairly ubiquitously made in cells across virtually every system. Although we think of it mainly as a respiratory disease, it is important to pay attention to all kinds of symptoms. People with diarrhea as the first symptom tend to present later in the course of infection and have worse outcomes. The virus is definitely able to replicate in the G.I. tract. It also seems to have systemic effects which remind me of severe sepsis with ARDS then MSOF, which is probably mediated by a cytokine storm. Obviously, age and pre-conditions like coronary artery disease, diabetes, and hypertension are important risk factors, but there is some combination of X factors that occasionally causes an otherwise healthy young doctor or nurse to crump & die. Genetics? Viral dose? Meds? Virus sub-strain? The good news is that the furin binding site on the spike protein presents an obvious target for drug therapy. Block that site and you block activation/infection.




https://www.medicalnewstoday.com/articles/why-does-sars-cov-2-spread-so-easily#Spike-protein-on-the-new-coronavirus

Spike protein on the new coronavirus

Spike proteins are what coronaviruses use to bind to the membrane of the human cells that they infect. The binding process is activated by certain cell enzymes.

SARS-CoV-2, however, has a specific structure that allows it to bind “at least 10 times more tightly than the corresponding spike protein of [SARS-CoV] to their common host cell receptor.”

Partly, this is due to the fact that the spike protein contains a site that recognizes and becomes activated by an enzyme called furin.

Furin is a host-cell enzyme in various human organs, such as the liver, the lungs, and the small intestines. The fact that this enzyme resides in all of these human tissues means that the virus can potentially attack several organs at once.