Wednesday, March 18, 2020 8:24:54 AM
Recently published study this month showing that there are positive psychologic effects of Ifenprodil in combination with modulation (decrease) in pro-inflammatory (bad) cytokines (markers of inflammation). My take from this is that patients who are treated with chronic cough might also have increased mood and "feel better" overall, in addition to objectively coughing less. They would likely also cough less because of the modulation of pro-inflammatory effects: here that is observed by a decrease in TNF-alpha, a potent inflammatory marker (it also decreased IL-1B and IL-6 inflammatory markers).
Who knows, maybe we should be doing a trial of this medication for depression also. Or perhaps a better use of this data would be to recognize that capturing mood data as a secondary outcome measure in their study for patients with chronic cough would be useful... The future is bright! The cool part about using repurposed drugs... they have proven safety.
*Note, this is an asian study, nobody is studying this like us in north america*
It has also been used to treat PTSD as seen here...
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