Clinical trial results will provide the ultimate answer. I consider it positive that the NCI is running such a trial. NCI sponsorship means little/no cost for Imclone, and also suggests a strong scientific rational for the combo.
Two Points
1. I would expect combined Erbitux + Tarceva to have bad skin/rash side effects. 2. With combo targeted therapies (like Erbitux and Tarceva) it may be possible to limit or eliminate chemotherapy, and all of its bad side effects.
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