Sunday, March 01, 2020 3:52:14 PM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839124/
From the IPIX coronavirus Blog PDF page 5 is an exciting article which showed inhaled defensins in an animal model reduced the death rate to zero. 75% of the controls died.
I believe that is why research scientist are looking at Brilacidin. ThePDE3/PED4 inhibition most likely plays a role in this effect. Reducing pulmonary inflammation and fibrosis may be the key to treating these critically ill patients.
https://static1.squarespace.com/static/5715352e20c647639137f992/t/5e59c166b728573d1b54f8dc/1582940526011/IPIX+Brilacidin+Defensin+Mimetics+-+COVID-19+Overview+Feb+2020+10pg+final.pdf
If the Brilacidin for coronavirus effectiveness is confirmed with in vitro testing at the biologic testing centers I would not be surprised to see Brilacidin in 2 arms in the subsequent FDA trials ,1 as an aerosol and a second IV infusion.
The aersol approval might open the door to Brilacidin aerosol for a number of pulmonary conditions:
asthma, COPD, cystic fibrosis,bronchiectasis, chronic bronchitis perhaps even inflammatory scarring disorders such as pulmonary fibrosis and pneumonconiosis.
It could be a bigger market than the GI market and if the government and if FDA facilitate the study it may be at little to no cost.
We will have to wait and see
GLTA and JMO,Farrell
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