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Alias Born 01/28/2020

Re: rogue2 post# 28933

Monday, 02/24/2020 11:52:07 PM

Monday, February 24, 2020 11:52:07 PM

Post# of 43716
It's an iterative model, guess hundred of survival curves until the right one is found.

Hi model author here,

This should explain it in Layman's terms.
For example,
if we assume MK patients' survival worsened by up to 5%, we should expect ~424 deaths by now, which obviously isn't the case, and hence the guess is too low.
if we assume MK has no benefit, we should expect ~390 deaths which obviously isn't the case, and hence the guess is too low.

if we assume MK has max 10% benefit, we should expect ~360 deaths which obviously isn't the case, and hence the guess is too low.

if we assume MK has max 50% benefit, we should expect ~300 deaths by now. Sounds about right, and just need to be tweaked a bit.

It took hundreds of KM iterations to get here =)

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