Cytodyn Inc (CYDY)

[ohm20]

Here is the thing - like HIV, K is the 100 pound Gorilla and has been approved for many indications with safety.

A 100 pound gorilla is a fairly small gorilla and is nothing to worry about.

This study shows 66% less PD-L1 in the absence of CCR-5. The bonus with leronlimab is that we also downregulate myeloid suppressor cells which have an even greater effect on tumor protection than PD-L1.

Moreover, the engagement of Treg CCR5 with its ligand CCL5 upregulates the expression of PD-L1, enhancing the inhibitory effect of
Tregs on neutrophil-derived MMP-9.

Real time polymerase chain reaction showed that CCL5 at a concentration of 0.04 lmol/L primed Tregs to express higher mRNA levels of the co-inhibitory cell surface molecule PD-L1 and the immunosuppressive cytokine interleukin-10 (IL-10) (Figure 8A). After CCL5 stimulation there was a trend toward increased mRNA expression of CD39, CTLA-4, and transcription factor FOXp3

https://www.ahajournals.org/doi/pdf/10.1161/JAHA.117.006387