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Re: Phoenix300 post# 399

Tuesday, 02/11/2020 4:40:12 PM

Tuesday, February 11, 2020 4:40:12 PM

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ProMIS discovery platform provides a unique competitive advantage, with an unparalleled track record of creating antibodies highly selective for the toxic molecular species
• ProMIS lead program PMN310 scientifically differentiated from Biogen’s aducanumab.
- Aducanumab is likely to be the first ever disease modifying therapy in AD, on track for potential approval in 2020
- Progress of aducanumab a potential catalyst for ProMIS
• Very active partnering market for preclinical assets in the neurodegenerative disease space, with attractive economics. ProMIS active discussions for alpha-synuclein, TDP43, and tau programs. ProMIS differentiation of highly selective antibodies that avoid physiologically important forms of those proteins critical for vectorization. Nearly all pharma partners interested in gene therapy vectorization
• Recent advances in fluid-based biomarkers will allow for early, cost-effective clinical proof of concept. potential pharma partners confirm strong interest in, and acceptance of, biomarker POC value
• ProMIS unique technology platform expanding the portfolio to additional mis-folded protein targets
• Numerous potential near-and medium-term catalysts
- Progress of aducanumab, approval, enhances expectations for PMN310 - Partnering deals
- Clinical POC
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