Thursday, December 07, 2006 4:07:47 PM
May2006 Vertex Ph.1B VX-950 Combo Trial data:
A median 1.0 log10 reduction in HCV RNA was observed in [genotype 1] patients receiving Peg-IFN alone at 14 days.
http://www.medicalnewstoday.com/medicalnews.php?newsid=42536
So, we have Peg-IFN alone after 14 days of treatment yielding either 1.0 log10 in the VX-950 1B trial, and 1.3 log10 in the ViroPharma HCV-796 trial (both for genotype 1 only).
Still no idea what Peg-IFN alone would be at 12 weeks followup after only 14 days treatment. Still looking…
= = = = = = = =
Aug2006 ViroPharma/Wyeth Ph.1B data for HCV-796, a non-nucleoside polymerase inhibitor:
• Consistent with known effects of pegylated interferon, response varied by HCV genotype:
• For genotype 1, mean reduction from baseline ranged from 1.5 to 2.3 log10 on day 7 and 2.6-3.2 log10 on day 14 in the combination therapy groups compared to 0.9 log10 on day 7 and 1.3 log10 on day 14 for pegylated interferon alone.
http://www.viropharma.com/therapeutic/hcv796.asp
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