Thursday, February 06, 2020 12:07:42 PM
Finally, we will be getting some inkling on what's going on w the Z20 trial. Last year, at Guggenheim, FL mentioned they were going to look at some fully annotated databases. I would love to know what they found out about ex20 historical efficacy using current SoC. Of course, the elephant in the room Q is 'Why did the results not come close to matching the MDACC trial results especially if patients were healthier than the Z20 patients'? One thing I remember JT saying during one CC was that one difference in the Z20 trial was that they would admit patients w brain mets. I wonder how many patients in the trial had them? Enough to make a difference? And every time I look at the ZENITH 20 Cohort 1 Waterfall Plot, I can't help but wonder why there were a considerable # of patients that had stable disease that had a 25 to near 30% response. It just seems like these patients would have hit 30% in the MDACC trial. Are there any theories why, such as these patients got off treatment earlier? Also, it seems that by the higher # of patients recruited than anticipated more patients were dropping out of this trial. Why? Anyhows, looking forward to the CC.
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