CytoSorbents Corporation (CTSO)

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Experience with hemoadsorption (CytoSorb) in the management of septic shock patients
Mehta Y, Mehta C, Kumar A, George JV, Gupta A, Nanda S, Kochhar G, Raizada A. World J Crit Care Med 2020 9(1): 1 - 12
02/2020
This retrospective case series included 100 adult patients who were admitted to intensive care between 2016 and 2018 in an Indian hospital following the diagnosis of sepsis or septic shock, who had been treated with dialysis and CytoSorb combination therapy. The authors used a new CytoSorb scoring (CS) system that was developed by a group of Indian clinicians for initiating CytoSorb therapy on the basis of their practical experience so far. The scoring system was derived from five parameters (hemodynamic, renal, respiratory, lab and sepsis scores), representing five different organ system which get affected in sepsis patients. This study proposes that the CytoSorb therapy should be recommended to the patients with scores between 8-13. In summary, results showed a reduction in the vasopressor dose, a significant reduction in cytokine levels, remarkable reduction in diagnostic markers such as PCT, CRP, bilirubin and serum lactate after the usage of CytoSorbtherapy. Early (preferably within <48 h after onset of septic shock) initiation could result in better clinical outcomes. CytoSorb was found to be safe and a well-tolerated rescue therapy option in patients with septic shock.
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