Cytodyn Inc (CYDY)

[MrGuru]

Vision and Value,
Interesting discussion.

As you know, during HIV-1 infection PD-1 and PDL-1 expression increase.

An study suggests that monocites and CCR5+ T cells of HIV-uninfected donors upregulated PDL-1.

It follows that a CCR5 antagonist will reduce the number of active CCR5+ cells effectively reducing PDL-1 expression.

In the same article it was mentioned that IFN-a-receptor subunit 2 (IFNAR2), was expressed only by CCR5+ T cells and monocytes, explaining why these leukocytes responded to HIV-induced IFN-a.

From : PDL-1 upregulation on monocytes and T cells by HIV via type I interferon: restricted expression of type I interferon receptor by CCR5-expressing leukocytes

I have the PDF document but you can find the paper in several sites. If needed let me know and I will forward via email.