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Thursday, January 23, 2020 7:34:07 PM
However even if we get 50% of patients going to CTC near zero - it will be great result - however he will have to show than in larger sample - minimum 50 patients.
There is also downside - he is showing great confidence to over confidence by going in basket trial. That is a gamble.
The CCR5 existence and impact in different types of cancer will be different. So in basket trial, the results are likely to be mixed and most likely to be inferior.
As mTNBC is showing great results, he should get basket trial protocol approved but not start the trial. Milk the mTNBC results as much as possible, move it further and then start enrollment in basket trial.
( I remember GALT trial on cancer in Standford - The TLR agonist did show some great results in 100% sample but very small number - as the time increased and sample increased - the results waned and now it is out of trial)
The patient 3-4 results are
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