Intellipharmaceutics Intl. Inc. (IPCIF)

[WeeZuhl]

It will all come down to the chewing and snorting HAL studies.

Ouch. Not only is it a total failure in both oral and intranasal drug liking studies, but snorting IPCI's formulation actually results in SUBSTANTIALLY higher blood concentrations of oxycodone when compared with snorted OxyContin and snorted OxyIR. Ruh-roh, Elmo.







https://www.fda.gov/media/134150/download

• The ground IPC oxycodone ER tablets were associated with 67% higher Cmax, 122%
and 97% higher partial AUCs (AUC0-1h and AUC0-2h, respectively), 26% higher AUCinf,
and 1.5 h earlier median Tmax compared to crushed oxycodone IR tablets.

• The ground IPC oxycodone ER tablets were associated with 64% higher Cmax, 78%
and 63% higher partial AUCs (AUC0-1h and AUC0-2h, respectively) and 0.5 h earlier
median Tmax compared to ground OxyContin tablets.

The mean drug liking for snorting and chewing is actually HIGHER for IPCI OxyEr than for either OxyContin or OxyIR.