Alaunos Therapeutics Inc (TCRT)

[jondoeuk]

''1)
In the Nov 26th 2019 PACT Pharma video -
President/Chief Tech Tim Moore says they will go after 1 Neoantigen and potentially as much as THREE.... you can suggest they are doing 4 and wayyy ahead if you want... But that's simply NOT THE CASE''

In the current trial, they are targeting a single neoantigen [1], but we know from the PR they will target more. This stated four [2] and I've heard more (sources I trust).

''2)
ZIOP has a Phase 2 - you try to dismiss/downgrade that all u want.''

Again, I know this. The estimated primary completion date is Dec 31, 2028 [3].

''3)
PACT Pharma has not DOSED as of Nov 26th per Tim Moore... in fact They have had to amend their IND several times.
You act like they are way ahead and yet they too have not DOSED... their Phase 1.''

Care to cite this video and the time at which Mr. Moore stated this?

''You would do well to look up Dr Rosenberg opinion of Neon/Gritstone and his discussion with Dr Michael Nishimura''

What does he say in them?

''Good luck catching $ZIOP with your Cancer Vaccines''

ZIOP's IL-12 has failed in melanoma, breast and has yet to show any activity in rGBM. We also know that they have been 'leapfrogged' in the CAR-T space and when it comes to vaccines GRTS have presented some early data on their vaccine [4].

Refs:
1 https://clinicaltrials.gov/ct2/show/NCT03970382
2 https://www.biocentury.com/bc-extra/preclinical-news/2019-07-22/pact-makes-case-neoantigen-specific-tcrs-patient-blood
3 https://clinicaltrials.gov/ct2/show/NCT04102436
4 https://www.fiercebiotech.com/biotech/gritstone-posts-one-most-potent-immunogenic-responses-for-a-neoantigen-vaccine