TAT0002
From Esammee's transcript of Lazard presentation this line made me think:
>>So what we have done is discovered from a traditional Chinese medicine extract a single entity, small molecule telomerase activator that's extremely specific and potent in upregulating telomerase activity in telomerase competent cells.<<
>>Telomerase competent cells !!<<
The concern of telomerase activation is if all the cells of the body would have their telomeres extended by an activator, increasing the possibility of creating cancers from cells with enough DNA mutations to only need TA to become cancerous.
Even this is somewhat remote due to the fact a Telomerase activator would be given for a limited time, whereas cancer cells have Telomerase turned on continuously. However like Micro says it wuld give them more throws of the dice to achieve a self sustaining cancer phenotype. OKarma has said however they have NEVER seen this in animal studies to date.
I suspect Telomerase Competent Cells refers to Adult Stem Cells that currently express some level of Telomerase, but as I understand Adult Stem Cells like CD8 T cells they do not produce enough to maintain telomere length in balance, but over time the telomeres erode to the point of senescence. Tissue types like skin that use adult stem cells to replace rapidly turning over cells with age loose youthful appearance and in the case of skin it wrinkles and becomes fragile and healing becomes more difficult. I suspect it is these Adult Stem Cells that are the target of TAT0002, giving their telomerase output a boost enough to extend their shortened Telomeres.
If this is the case TAT0002 has the potential to restore a more youthful phenotype to all aged tissue that rely on adult stem cells for maintainance. I remember a TV presentation with Tom OKarma where they showed cells that had their Telomeres extended due to TA have regained a youthful appearance and behaviour compared to the control group of sibling cells.
When Tom OKarma referred to TAT002 having the potential equal to GRN163L he maybe wasn't kidding. A simple pill on a regular schedule restoring the function of aged tissues from Skin to Liver would be an incredible product
Bob
