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Re: DewDiligence post# 11

Monday, 12/04/2006 11:59:36 PM

Monday, December 04, 2006 11:59:36 PM

Post# of 3757
>> Are you impressed with how similar Viread and Hepsera are? They are almost as similar as Tyzeka and Clevudine. <<

It is amazing when you think about the specificity of biological systems. In 2D many of these molecules are absolutely identical , but in the real 3D world the differences are sufficient to make them behave like unrelated compounds. It must make modelling of drug-protein interactions a nightmare when you start combining two or more of these drugs.