Tuesday, December 10, 2019 1:15:52 PM
I still can't get the fact out of my head that Astra Zeneca CEO mentioned them in his PR and they are looking for partners, etc. so maybe after this presentation someone from the big leagues will step in.
1:50 pm TSC Treats GBM by Reducing Hypoxia: A Novel Approach
John Gainer
Chief Scientific Officer, Co-founder, Diffusion Pharmaceuticals
Synopsis
• Novel mechanism of action of TSC results in safe, effective oxygenation of any type of hypoxic tissue. Developed originally for treatment of battlefield casualties
• TSC added to chemo-radiation in Phase 2 open-label clinical study shows considerable tumor shrinkage. Survival for biopsy-only patients increases by a factor of 4, equalling the survival for those patients initially having complete resections
• No serious adverse events attributed to TSC, suggesting a very safe drug.
Functional status of patients excellent over 2 years of clinical trial
• Lead-in to a Phase 3 randomized clinical trial for biopsy-only patients suggeststhat also adding TSC to adjunct chemotherapy portion of GBM frontline treatment is safe and extends survival time
John Gainer
Chief Scientific Officer, Co-founder
Diffusion Pharmaceuticals
BS, MS, PhD; Chief Science Officer of Diffusion Pharmaceuticals Inc., Charlottesville, Virginia, USA; Professor for 40 years at University of Virginia with sabbaticals at Pharmacology Department, Karolinska Institute, Stockholm, Sweden and ICI Pharmaceuticals, Alderley Edge, England; invented TSC for treating battlefield casualties under grant from US Office of Naval Research.
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