Relmada Therapeutics Inc. (RLMD)

[Biobonic]

From the international patent application dtd Sept 2013

Titled: Title: D-METHADONE FOR THE TREATMENT OF PSYCHIATRIC SYMPTOMS

submitted by Paulo Manfredi with inventor Charles Inturrisi.


Both d-methadone and l-methadone are NMDA antagonists. Only l-methadone binds to opioid receptors. Treatment with d-methadone results in
NMDA antagonism without opioid receptor activity. [See Gorman, A.L., Elliott,K.J. and Inturrisi, C.E., The d- and I- isomers of methadone bind to the non competitive site on the N-methyl-D-aspartate (NMDA) receptor in rat forebrain and spinal cord, Nerurosci Lett, 223 (1997) 5-8, incorporated by reference herein in its entirety.]

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