ISEE isn’t getting much respect because it’s the renamed OPHT, whose Fovista failed horrifically in wet AMD (#msg-148256773, #msg-127913009, #msg-127173982, #msg-133812911). As for Zimura... it, too, was a wet-AMD drug that’s been repurposed for dry AMD (https://www.mdmag.com/medical-news/zimura-lucentis-combo-safe-but-company-decides-not-to-move-forward ); it might work, of course, but I wouldn’t bank on it.