RespireRx Pharmaceuticals Inc (RSPI)

[gfp927z]

Dew, Thanks for the article. I had heard of the "chemobrain" phenomenon, but was not aware that chemo agents could be so extremely toxic to brain cells. An Ampakine might reduce the cognitive impairments associated with the chemo, representing a gigantic new indication for Ampakines (if we can manage to get a compound past Phase 2..)

So far -

Biarylpropylsulfonamides - bombed out in Phase 2 (LY-451395)

Benzothiadiazines - bombed out in Phase 2 (S-18986)

Benzamides - 1) CX-516 - too weak
2) Org-24448 - still going in multi Phase 2,
3) CX-717 - ?