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Tuesday, October 22, 2019 6:43:39 AM
1) indeed. Also, they could have stated 96% completion and be in reality at 98% in terms of events (as for Modus 98% while trial completed). Does it mean that we could be closer from completion like 5 events away ?
2) I don't believe in "lower dropouts rates" anymore. Fact that SOC is so bad means necessarily that Dropouts are high otherwise trial would have ended early and positively. Hopefully dropouts contained under 20% overall for all sites.
3) All deaths are counted for in the 298, including road incidents, that's the way the trial is designed. This is why it is called "overall survival" as opposed to relative. Trial design will compare superiority of MK arm versus SOC whatever cause of death in both arms.10 % or more less death in MK arm and its a success. NB : Most of them will be due to this cancer (there is a 2 to 5% difference between relative and observed survival)
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