Predictive Technology Group Inc (PRED)

[ThomasHBS-HLS]

What's going on within PRED's Predictive Biotech

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Mesenchymal Stem Cells for Regenerative Medicine
Cells. 2019 Aug; 8(8): 886. Published 2019 Aug 13. doi: 10.3390/cells8080886
"MSCs exist in various tissues and organs apart from bone marrow, with multilineage cells from human umbilical cord blood, first reported in early 2000."
"Umbilical cord blood-derived MSCs (UCB-MSCs) exhibit biological advantages relative to other adult sources, including their capability for longer culture times, larger-scale expansion, more significant retardation of senescence, and higher anti-inflammatory effects."

The potential of mesenchymal stem cells derived from amniotic membrane and amniotic fluid for neuronal regenerative therapy
BMB Rep. 2014 Mar; 47(3): 135–140.
"Recently, many studies have identified amniotic fluid (AF) as a new source of MSCs, and these AF-MSCs express the pluripotent marker Oct-4 in almost 90% of the active condition, and they also have multiple differentiation capacity like the AM-MSCs. Further, AF is routinely used to perform the standard evaluation of karyotyping and they are genetic and molecular tested for diagnostic purposes."

Neurodegeneration and Neuro-Regeneration—Alzheimer’s Disease and Stem Cell Therapy
Int J Mol Sci. 2019 Sep; 20(17): 4272. Published 2019 Aug 31. doi: 10.3390/ijms20174272
"Mesenchymal stem cells are multipotent stromal cells that can be isolated from various organs and tissues, such as bone marrow (BM-MSCs), umbilical cord (UCB-MSCs), adipose tissue (AD-MSCs), peripheral blood, amniotic fluid, muscle and lung. MSCs can differentiate into a variety of cells types, are highly proliferative and are easily accessed and easily handled."
"MSCs can also be applied intravenously, as these cells are able to cross the blood-brain barrier and travel to the injury site, which offers enormous benefits for patient treatments."
"Similarly to other types of stem cell transplantation effects, transplantation of MSCs reduced Aß deposits and tau-phosphorylation, increased neurogenesis and provided support with secreted factors and improved learning and memory deficits. Immune modulating and anti-inflammatory effects have also been observed, through the upregulation of neuroprotective and downregulation of pro-inflammatory cytokines."

Embryonic Stem Cell-Derived Mesenchymal Stem Cells (ES-MSCs) Have a Superior Neuroprotective Capacity Over Fetal MSCs in the Hypoxic-Ischemic Mouse Brain.
Stem Cells Transl Med. 2018 May; 7(5): 439–449. Published 2018 Feb 28. doi: 10.1002/sctm.17-0260
"ES-MSCs Have Enhanced Neuroprotective Potential in Comparison to AF-MSCs."
"NF-?B-induced IL-13 production contributes to the increased anti-inflammatory potential of ES-MSC-CM compared with AF-MSC-CM."