Friday, August 23, 2019 2:59:04 PM
The short answer is yes.
The "major mds" are paid consultants. And someone like Hildago is a consultant for multiple companies. If he gets for example $20K a piece from half a dozen companies for 2X per yr consults, it adds up.
From the science end there is no evidence Metronomic chemo with an alkylating agent is a viable treatment. It never has worked as a monotherapy for solid tumors. Too easy for chemo resistance to occur. It might initially shrink tumors for 1st line patients, but the tumor will come back. Kenny wants to stage his mythical CT with 2nd line patients. Likely to have a thicker more dense stromal layer around the primary tumor. Perform a Goog on "pancreatic cancer chemo resistance stromal layer", and read up on it.
Kenny has been peddling this idea Metronomic Ifosfamide+CIABs will cause the tumor infiltration to fall off the walls of the artery, and presto the tumor is removed. Perform a Goog on "What makes a pancreatic tumor resectable", and read about it. Not that simple is it?
Kenny keeps peddling the idea the FDA will allow Phase 1, 2a to be skipped. Which would a first in the history of the FDA. Try to find a CT where Phase 1 dose/toxicity was not conducted first. He claims the Lohr ad hocs from 1999 could be a subsitute. That would be another FDA first. Consult the FDA site.
If Metronomic Ifosfamide+CIAB was going to induce some miracle response, then big pharma especially in the EU, would've been pouring money into Austrianova and/or partnering with them back in 2003. Instead AN went BK. The industry passed judgement on the treatment close to 20 yrs ago. And it isn't because they didn't know about it.
In another 5 yrs there will likely be a potential to treat, and cure PC. It will be done with initially a combo of front line chemo+targeted pathway drugs+immunotherapy. Eventually the chemo will no longer be required, but that will take more time. However, it will not be accomplished with Metronomic Ifosfamide chemo, plus/minus CIABs.
Diabetes? Currently the FDA mandates any implanted encased stem cells be retrievable, since stem cells can turn cancerous. How would they feel about Melligen cells derived from a cancerous liver cell line? If that hurtle is jumped over, then one has the likes of Lilly, Novartis, and a couple others with years worth of lead time, and an ample supply of internal funding. While PMCB tries to figure out how to retrieve the CIABs.
THC for brain cancer? Would you rather have a hole drilled in your skull to insert the magic CIABs onto your brain issue, or just swallow an oral THC derivative, not needing any conversion? There's a company already in CTs with an oral medication. Again, years ahead of PMCB. Also only one form of brain cancer has responded to cannabinoids.
Then one should take the appropriate action based on beliefs.
The Jewel of the Mind is Colored with the Hue of what it Imagines
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