Just to touch on a few of your points.
- Apparently PKCe plays an important part in childhood brain development, which Bryostatin activates again
Isn't it amazing how many things in life (biologically in particular) come full circle that are important in children and become an issue in elderly?
- An explanation for why it could be used preventatively: It not only activates PKCe but also regulates the gene responsible for making it
It's just one of those intuitive elements but he states the models have shown that the drug can repair transcription issues in the genes. Not only has it shown to regulate the gene, it apparently regulates the quantity of PKCe as well per his statement today and that's why it could be used to stem AD before it ever occurs. He mentioned that the PKCe test kit Neurodiagnostics has applied for FDA device approval could play a role in identifying AD patients
- Had "very very positive results" in stroke models and managed to reverse the damage caused by the stroke, not only in strokes caused by blood clots, but also in the ones caused by hypoxia where neurons are destroyed because of blood failing to reach the brain (for example because of anesthesia during surgeries, hanging, strangulation, carbon monoxide poisoning and near-drowning)
To me this was very interesting as the SA author made a recent reply that part of AD pathology was hypoxia and due to this fact bryostatin could never treat AD in a blanket statement that wasn't explained. Once again this is more than laughable IMO and she was called out on it but didn't respond.
- Believes regenerative treatments are going to be the "way of the future"
Very interesting if this trial pans out and to see just how true his opinion is. Also very interesting that amount of similar MOA drugs that we have in the background that can be tested otherwise known at the PUFA derivatives.
In general he explains a lot of what we already know in a detailed way that's easy to understand, so that's nice too.
I always love the matter of fact way he explains this stuff like why no other animals or species or whatever get alzheimer's and why that might be relative to bryostatin as a treatment or about the reason the pkce treatment with bryostatin induces so many different modalities.
No matter the amount of new information provided in these interviews, just by listening you can understand the depth of knowledge in ALL AD processes that he possesses right off the top of his head. Of course he's been doing it for 40 years. I'm 100% rooting for this guy regardless of my investment here.
