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Stopping the spread of pancreatic cancer
by Arlene Weintraub | Aug 12, 2019 9:35am
Pancreatic cancer
Reducing perlecan in mouse models of pancreatic cancer slowed metastasis and improved the response to chemotherapy. (By Manu5, via Wikimedia Commons)

Pancreatic cancer is one of the toughest forms of the disease to treat, because it often causes no symptoms until it has spread beyond the pancreas. Now, a team led by the Garvan Institute of Medical Research in Australia has discovered one method by which pancreatic cancer cells spread and shield themselves from chemotherapy—a finding that could provide a new two-pronged approach to treating the disease, they said.

The researchers discovered that some pancreatic tumors overproduce perlecan, a type of protein that helps cancer cells change the “cellular matrix”—the tissue that holds tumors together. That remodeling of the tumor's environment allows cancer cells to travel to other parts of the body. The perlecan also seems to protect the cells from chemotherapy.

The team lowered levels of perlecan in mouse models of pancreatic cancer and observed a drop in the spread of the cancer and an improvement in the response to chemotherapy. They reported their findings in the journal Nature Communications.

Rest of the story:

https://www.fiercebiotech.com/research/stopping-spread-pancreatic-cancer?mkt_tok=eyJpIjoiT0RkaE56UmhOR1EwWmpFeCIsInQiOiI1RkJRSUk4VEJld0ZkdXJjd2o2amJzR0JcL21cL2R1V1F6YVdVVmtiMTlqdzV1bFpXZWloUWgyVDMzNTI4WU8rVlpCQjBGd2E3VlNTNDJOdmNrbitHVGZUbVFSQXlabmVzUkltXC81Tk9iakVMNm1uVThWdHVoSWU0ZzcxN3gwemw1RyJ9&mrkid=68926271

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