In other words, Opdivo + (low-dose) Yervoy bested chemo regardless of PD-L1 expression, but only the PD-L1-positive subgroup had been assigned alpha.
Here’s the bad part:
The OS HR for Opdivo/chemo vs chemo alone in this patient pool was 0.86 with a 95% CI of [0.69-1.08], according to data posted on BMY’s website.
OS HR=0.86 is not terrible, but this is a patient pool where Keytruda/chemo showed statsig better OS than chemo alone with HR=0.49, so Opdivo has again underperformed relative to Keytruda.
BMY’s 2Q19 CC is tomorrow. Expect plenty of discussion on CHECKMATE-227 in all of its manifold components!
See the quoted section of #msg-146308018 for related info.
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