Avid Bioservices Inc (CDMO)

[biopharm]

Italian researchers well aware of Phosphatidylserine as Biomarkers ...the question is what is Oncologie CEO Laura Benjamin doing with all this research

Avid Bioservices set to receive royalties milestones etc etc based upon PS Targeting / Biomarkers etc

Also look how some authors such as Lamya Garabet from 2017 to 2019, realizing how it is due to flipped PS to find where the trouble begins with ITP Immune Thrombocytopenia

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July 7, 2019

Searching for Potential Lipid Biomarkers of Parkinson’s Disease in Parkin-Mutant Human Skin Fibroblasts by HILIC-ESI-MS/MS:

Preliminary Findings

Cosima D. Calvano 1,2,*,
Giovanni Ventura 1,
Anna Maria M. Sardanelli 3,4,*,
Laura Savino 3,
Ilario Losito 1,2,
Giuseppe De Michele 5,
Francesco Palmisano 1,2 and
Tommaso R. I. Cataldi 1,2

1 Dipartimento di Chimica, Universita` degli Studi di Bari Aldo Moro, via Orabona 4, 70126 Bari, Italy

2 Centro Interdipartimentale SMART, Universita` degli Studi di Bari Aldo Moro, via Orabona 4, 70126 Bari,
Italy

3 Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari “Aldo Moro”,
70100 Bari, Italy

4 Department of Medicine, Campus Bio-Medico University of Rome, 00128 Roma, Italy

5 Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples
Federico II, 80131 Naples, Italy
*
Correspondence:[e-mail](C.D.C.);[e-mail](A.M.S.)

Received: 29 May 2019;
Accepted: 5 July 2019;
Published: 7 July 2019

https://res.mdpi.com/ijms/ijms-20-03341/article_deploy/ijms-20-03341.pdf?filename=&attachment=1

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PROFILING CIRCULATING MICRORNAS IN PATIENTS WITH IMMUNE THROMBOCYTOPENIA (ITP) TO EXPLORE THE ROLE OF MICRORNAS AND POSSIBLE BIOLOGICAL PATHWAYS INVOLVED IN THE PATHOGENESIS OF ITP

Author(s):

Lamya Garabet ,
Waleed Ghanima ,
Anbjørg Rangberg ,
Raul Teruel-Montoya ,
Constantino Martinez ,
James B. Bussel ,
Per Morten Sandset ,
Christine Monceyron Jonassen
EHA Library. Garabet L.

May 18, 2017; 181210; E1434

https://library.ehaweb.org/eha/2017/22nd/181210/lamya.garabet.profiling.circulating.micrornas.in.patients.with.immune.html

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Increased microvesicle-associated thrombin generation in patients with immune thrombocytopenia after initiation of thrombopoietin receptor agonists

Lamya Garabet,
Waleed Ghanima,
Marit Hellum,
Per Morten Sandset,
James B. Bussel,
Hoa Tran &
Carola E. Henriksson

show less

Received 11 Apr 2019,
Accepted 28 Jun 2019,
Published online: 07 Jul 2019

Abstract
Immune thrombocytopenia (ITP) patients have thrombocytopenia and increased bleeding risk, but, conversely, they also have increased thrombotic risk which appears to be exacerbated by thrombopoietin-receptor agonist (TPO-RA)-treatment. Microvesicles (MVs) released from activated/apoptotic cells are prothrombotic due to exposure of phosphatidylserine (PS) and tissue factor (TF). MVs are increased in ITP patients, but their prothrombotic effect, before and during treatment with TPO-RAs, is unclear.

We studied the effect of TPO-RAs on the procoagulant activity of MVs in 11 ITP patients, before, and two and six weeks after initiation of treatment, and in 15 healthy controls. MV-associated PS-activity, TF-activity and the capacity of isolated MVs and plasma to generate thrombin in a phospholipid-dependent manner were measured.

Before treatment with TPO-RAs, prothrombotic markers in ITP patients were comparable to levels found in healthy controls. After both two and six weeks of TPO-RA-treatment, ITP patients had higher MV-associated PS-activity and phospholipid-dependent thrombin generation in plasma than controls. In addition, ITP patients had increased phospholipid-dependent MV-associated thrombin generation two weeks after initiation of TPO-RA-treatment compared with controls and pre-treatment levels. MV-associated TF-activity was low in controls and in ITP patients before and after initiation of TPO-RA-treatment.

In conclusion, TPO-RAs increase phospholipid-dependent MV-associated thrombin generation in ITP patients. This could contribute to or exacerbate a pre-existing hypercoagulable state. Phospholipid-dependent thrombin generation generated by isolated MVs, or measured directly in plasma, may be potential tools that could help in the risk-assessment of future thromboembolic events in ITP patients, both before and after initiation of TPO-RA-treatment.

https://www.tandfonline.com/doi/full/10.1080/09537104.2019.1639655?scroll=top&needAccess=true

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