Innovation Pharmaceuticals Inc (IPIX)

[farrell90]

Another JAK inhibitor... Pfizer's JAX inhibitor, Xeljanz, is currently approved for treatment of Ulcerative Colitis. And it has already earned a black box warning for multiple infectious diseases and cancer which could lead to death.

Perhaps a safer solution will be developed.

Good luck,Farrell

WARNING: SERIOUS INFECTIONS AND MALIGNANCY
See full prescribing information for complete boxed warning.

Serious infections leading to hospitalization or death, including tuberculosis and bacterial, invasive fungal, viral, and other opportunistic infections, have occurred in patients receiving XELJANZ. (5.1)
If a serious infection develops, interrupt XELJANZ/XELJANZ XR until the infection is controlled. (5.1)
Prior to starting XELJANZ/XELJANZ XR, perform a test for latent tuberculosis; if it is positive, start treatment for tuberculosis prior to starting XELJANZ/XELJANZ XR. (5.1)
Monitor all patients for active tuberculosis during treatment, even if the initial latent tuberculosis test is negative. (5.1)
Lymphoma and other malignancies have been observed in patients treated with XELJANZ. Epstein Barr Virus-associated post-transplant lymphoproliferative disorder has been observed at an increased rate in renal transplant patients treated with XELJANZ and concomitant immunosuppressive medications. (5.2)