Cel Sci Corporation (CVM)

[staticmirror79]

Fosco, Lightrock, and anyone else who is looking for survival statistics.

Did a slightly different google search and came across what I think is a VERY useful study which is very similar (not exactly the same, but close) to our Multikine study. The data looks very sobering for cancer patients (promising for multikine study, but still sad to see). Lots of useful info in there. I would check out table 2 survival statistics. But spend some time looking everything over. I really do think this is one of the best studies with statistics that's extremely close to our study. After reading this, I would realistically say we are probably somewhere between CVM's survival and our 63% realistic survival. I think we have been overly conservative if anything. Let me know what you think/find (it was pretty dense reading)

Take a look at table 2

Highlights:
-This is a 50 year chinese study for 3,362 patients. They started in 1960 and went to 2009 (5 year follow up to 2014).
-Wished to know whether or not clinical features and survival rate have changed over time for OCC (oral cavity cancer)patients receiving initial treatment and follow-up at a large cancer center in China.
-Five-year overall survival of patients diagnosed with oral cavity cancer from 2000-2009 was 55.6% (this includes all stages, not just stage 3 and 4 like multikine has)
-From the 1960s to the 2000s, the 5-year survival rate steadily improved from 47.8% to 55.6% (about 8%)(this is inline with foscos realistic spreadsheet, but again this was all stages)
-Early diagnoses and treatments remain pivotal to improved survival rates
-Followup of vital status was performed until June 2015. and 94.3% of patients had follow-up into the fifth year after initial therapy. (good example of dropout percentage?)
-Base of tongue and soft palate cancers were excluded, but lip, tongue, other parts of oral cavity were included (from what i understand, the cancers that were excluded are more deadly)
-Chart c on table 2 shows that squamous cell is more deadly.
-at 5 years survival ranged from 59.6% to 30% depending on the age
-Local cancer (stage 1 and 2) which we don't have in our study but they had in theirs, really bumps up the survival numbers
-Table S3 and Figure S4 show that the overall 5-year survival rate was 38.7%, 42.2%, 48.1%, and 44.8%, for cancers of the gingiva, floor of mouth, hard palate, and buccal mucosa, respectively.
-In comparison, the overall 5-year survival rates of tongue cancer in developed countries were as follows: USA 63.4%,13 Germany 44.9% (male)/56.0% (female),11 Denmark 35/45%, Finland 50/68%, Norway 48/58%, and Sweden 46/56%.14 In general, the aforementioned data indicate a tendency toward similar survival rates between the USA and this study and slightly higher survival rates for oral tongue cancer patients in this study than observed in European countries.

Again, I really think this is a great resource. Someone might find, or know something in here that I haven't caught either. (please be critical in looking this over, fact check me and make sure that what I extrapolated was correct. If a few people can read this and verify the same things I have, then we are looking fantastic in terms of success for Multikine and Phase 3

Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190823/