Avid Bioservices Inc (CDMO)

[biopharm]

Janssen would be a nice CDMO 1st wave

It will be interesting how they will try to pressure a sale before the 3rd 4th and 5th waves roll in

The buzz is that PS Targeting will be the final momentum wave that disrupts Big Pharma as we now know it and a major lawsuit looms for some that don't realize how to adjust

Maybe John Springs Stafford has time to stop buzzing around and realize how criminal it would be to collude with hedge funds to manipulate CDMO and think again regarding his comments surrounding PS Targeting

Some knew long ago the value of PS Targeting so why did Stafford want a PS Targeting deal finalized before the value was fully realized. Maybe because the value deal made with Oncologie was peanuts

I wonder if some new hedge fund invested in CDMO realizes that the real value driver is PS Targeting and not CDMO. CDMO looks like it will simply be paid off with many manufacturing agreements "based" upon PS Targeting

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"Cancer therapies that attack the lipid composition of the cell membrane would be an entirely new class of anticancer drugs," said Paul Beales from the University of Leeds and co-author of the study. "This could be useful in developing new combination therapies, where multiple drugs are used simultaneously to treat a cancer by attacking different parts of the cancer cells at the same time."

In healthy cell membranes, the inner layer (facing the inside of the cell) is packed with phospholipids, including PS (phosphatidylserine) and PE (phosphatidylethanolamine). However, in cancer cells, PS and PE are located on the outer layer of the cell membrane, facing the opposite way.

To test the different effects of PS and PE's presence on a cell, the scientists examined how the MP1 interacted with model membranes infused with PE and/or PS. The presence of each phospholipid had a destructive effect on the cells. PS increased the chance of MP1 binding to the membrane by a factor of seven to eight. The presence of PE inflated the size of the holes created by the MP1 by a factor 20 to 30.

"Formed in only seconds, these large pores are big enough to allow critical molecules such as RNA and proteins to easily escape cells," said João Ruggiero Neto from São Paulo State University and co-author of the study. "The dramatic enhancement of the permeabilization induced by the peptide in the presence of PE and the dimensions of the pores in these membranes was surprising."

The next stage for this research is to adjust the amino acid sequence of MP1 to see what gives it its selective properties, and to try and refine them. "Understanding the mechanism of action of this peptide will help in translational studies to further assess the potential for this peptide to be used in medicine," Beales says. "As it has been shown to be selective to cancer cells and non-toxic to normal cells in the lab, this peptide has the potential to be safe, but further work would be required to prove that."

https://www.iflscience.com/health-and-medicine/brazilian-wasp-venom-kills-cancer-cells-not-healthy-cells/