![](http://investorshub.advfn.com/images/default_ih_profile2_4848.jpg?cb=0)
Friday, May 10, 2019 12:17:15 PM
Dosage of TiO2 in tissues was performed by ICP-AES and revealed an important accumulation of TiO2 in the liver. The nanoparticles induced morphological and physiological alterations in liver and kidney. In the liver, these alterations mainly affect the hepatocytes located around the centrilobular veins. These cells were the site of an oxidative stress evidenced by immunocytochemical detection of 4-hydroxynonenal (4-HNE). Kupffer cells are also the site of an important oxidative stress following the massive internalization of TiO2 nanoparticles. Enzymatic markers of liver and kidney functions (such as AST and uric acid) are also disrupted only in animals exposed to highest doses. The metabonomic approach allowed us to detect modifications in urine samples already detectable after 4 days in animals treated at the lowest dose. This metabonomic pattern testifies an oxidative stress as well as renal and hepatic alterations.
https://www.hindawi.com/journals/jt/2019/5767012/
Recent SINT News
- Form 8-K - Current report • Edgar (US Regulatory) • 07/11/2024 08:45:11 PM
- Form 424B5 - Prospectus [Rule 424(b)(5)] • Edgar (US Regulatory) • 07/11/2024 08:15:48 PM
- SINTX Technologies to Explore Strategic Opportunities • GlobeNewswire Inc. • 06/18/2024 01:00:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 06/12/2024 01:05:12 PM
- SINTX Technologies Regains Compliance with Nasdaq Bid Price Requirement • GlobeNewswire Inc. • 06/12/2024 01:00:00 PM
- SINTX Technologies Receives Additional SBIR Contract for 3D Printing Technology • GlobeNewswire Inc. • 06/06/2024 01:00:00 PM
- SINTX TECHNOLOGIES SIGNS AGREEMENT TO ENTER KOREAN TECHNICAL CERAMICS SECTOR • GlobeNewswire Inc. • 05/29/2024 01:00:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 05/23/2024 01:10:13 PM
- SINTX TECHNOLOGIES ANNOUNCES REVERSE STOCK SPLIT EFFECTIVE MAY 28, 2024 • GlobeNewswire Inc. • 05/23/2024 01:00:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 05/15/2024 01:00:29 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 05/13/2024 09:20:34 PM
- SINTX AND PRODWAYS AGREE ON CERAMIC SLURRY SUPPLY AND 3D PRINTING AGREEMENT • GlobeNewswire Inc. • 04/29/2024 01:14:20 PM
- SINTX Technologies Announces Pricing of $1.5 Million Public Offering of Common Stock • GlobeNewswire Inc. • 04/03/2024 01:00:00 PM
- SINTX Technologies Announces Proposed Public Offering of Common Stock • GlobeNewswire Inc. • 03/29/2024 08:00:00 PM
- SINTX Technologies Announces Pricing of $1.3 Million Public Offering of Common Stock • GlobeNewswire Inc. • 03/25/2024 01:00:00 PM
- SINTX Technologies Announces Proposed Public Offering of Common Stock • GlobeNewswire Inc. • 03/22/2024 12:30:00 PM
- SINTX TECHNOLOGIES ENTERS INTO A SECOND LONG TERM SUPPLY AGREEMENT FOR THE AEROSPACE MARKET • GlobeNewswire Inc. • 02/21/2024 02:00:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 02/14/2024 02:00:28 PM
- Form SC 13G/A - Statement of acquisition of beneficial ownership by individuals: [Amend] • Edgar (US Regulatory) • 02/14/2024 01:12:54 AM
- Form SC 13G - Statement of acquisition of beneficial ownership by individuals • Edgar (US Regulatory) • 02/07/2024 09:42:32 PM
- SINTX Technologies Announces Closing of $4.0 Million Public Offering • GlobeNewswire Inc. • 02/02/2024 07:33:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 02/02/2024 11:30:20 AM
- Form 424B4 - Prospectus [Rule 424(b)(4)] • Edgar (US Regulatory) • 02/01/2024 10:14:28 PM
- Form EFFECT - Notice of Effectiveness • Edgar (US Regulatory) • 02/01/2024 05:15:22 AM
- SINTX Technologies Announces Pricing of $4.0 Million Public Offering • GlobeNewswire Inc. • 01/31/2024 02:20:00 PM
FEATURED Southern Silver Files NI43-101 Technical Report for its Updated Preliminary Economic Assessment for the Cerro Las Minitas Project • Jul 25, 2024 8:00 AM
Greenlite Ventures Completes Agreement with No Limit Technology • GRNL • Jul 19, 2024 10:00 AM
VAYK Expects Revenue from First Airbnb Property Starting from August • VAYK • Jul 18, 2024 9:00 AM
North Bay Resources Acquires Mt. Vernon Gold Mine, Sierra County, California, with Assays up to 4.8 oz. Au per Ton • NBRI • Jul 18, 2024 9:00 AM
Nightfood Holdings Signs Letter of Intent for All-Stock Acquisition of CarryOutSupplies.com • NGTF • Jul 17, 2024 1:00 PM
Kona Gold Beverages Reaches Out to Largest Debt Holder for Debt Purchase Negotiation • KGKG • Jul 17, 2024 9:00 AM