Pfizer Inc (PFE)

[DewDiligence]

FDA approves PFE’s tafamidis for ATTR—US list price is $225K per year:

https://finance.yahoo.com/news/pfizer-gets-u-approval-225-110442534.html
https://finance.yahoo.com/news/u-fda-approves-vyndaqel-vyndamax-104500860.html

Pfizer, which has touted tafamidis as a potential blockbuster product, set a list price of $225,000 a year for the medicine, which would be sold under the brand name Vyndaqel. It is the first approved medicine for the disease in the United States… The FDA also approved another oral formulation of tafamidis under the brand name Vyndamax, with a recommended dose of either Vyndaqel 80 mg once-daily, taken as four 20 mg capsules or Vyndamax 61 mg once-daily, taken as a single capsule.

… Pfizer believes there are about 100,000 people in the United States with the condition, the vast majority undiagnosed. Only about 2,000 to 5,000 patients are currently diagnosed with the progressive heart disease globally… Pfizer believes there could be 400,000 to 500,000 patients in developed markets around the world and said the current rate of those diagnosed may be as low as 0.5 percent to 1 percent.

…Analysts are forecasting annual sales to exceed $1 billion in 2024…

…Vyndaqel currently sells for about $100,000 a year outside the United States as a treatment for FAP. It was approved in Japan for transthyretin amyloid cardiomyopathy in May at a price of around $750,000 a year that was set by a government body, Pfizer said.

…Alnylam Pharmaceuticals and Ionis Pharmaceuticals Inc have approved medicines that treat a similar disease called hereditary TTR amyloidosis, also caused by a buildup of transthyretin protein in the body. Those drugs cost around $450,000 a year.

*Brand names Vyndaqel and Vyndamax.