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Re: InTheTrenches post# 10260

Sunday, 05/05/2019 2:21:44 PM

Sunday, May 05, 2019 2:21:44 PM

Post# of 21531
Nope, the best match is #3:


3. Dose-response Concurrent Control (1.3.3)
In a randomized, fixed-dose, dose-response trial, subjects are randomizedt o one of several fixeddose groups. Subjects may either be placed on their fixed dose initially or be raised to that dose gradually, but the intended comparison is between the groups on their final dose. Dose-response trials are usually double-blind. They may include a placebo (zero dose) and/or active control. In a concentration-controlled trial, treatment groups are titrated to several fixed-concentration windows; this type of trial is conceptually similar to a fixed-dose, dose-response trial. In a regimen-controlled trial subjects are randomized to two or more regimens of the study drug (e.g., once vs. twice daily, 3 days vs. 7 days).





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