Sorrento Therapeutics Inc (SRNE)

[XenaLives]

Lidocaine transdermal patch - Scilex Holding
Alternative Names: Lidocaine 1.8% patch - Scilex Holding; ZTlido
Latest Information Update: 27 Mar 2019

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At a glance
Originator Scilex Pharmaceuticals
Developer Scilex Holding
Class Acetanilides; Class Ib antiarrhythmics; Local anaesthetics; Non-opioid analgesics; Small molecules
Mechanism of Action Sodium channel antagonists
Orphan Drug Status No
New Molecular Entity No
Highest Development Phases
Marketed Postherpetic neuralgia
Most Recent Events
22 Mar 2019 Semnur Pharmaceuticals has merged with Scilex Pharmaceuticals to form Scilex Holding
01 Oct 2018 Launched for Postherpetic neuralgia in USA (Transdermal)
11 Sep 2018 9249023- Reworded intro, updated KDM, FE, TT, AE and HE. Thes request sent for addition of DC: non-opioid analgesics

https://adisinsight.springer.com/drugs/800040288

Postherpetic neuralgia

Overview
Postherpetic neuralgia (post-hur-PET-ik noo-RAL-juh) is the most common complication of shingles. The condition affects nerve fibers and skin, causing burning pain that lasts long after the rash and blisters of shingles disappear.

The chickenpox (herpes zoster) virus causes shingles. The risk of postherpetic neuralgia increases with age, primarily affecting people older than 60. There's no cure, but treatments can ease symptoms. For most people, postherpetic neuralgia improves over time.

Symptoms
The signs and symptoms of postherpetic neuralgia are generally limited to the area of your skin where the shingles outbreak first occurred — most commonly in a band around your trunk, usually on one side of your body.

Signs and symptoms might include:

Pain that lasts three months or longer after the shingles rash has healed. The associated pain has been described as burning, sharp and jabbing, or deep and aching.
Sensitivity to light touch. People with the condition often can't bear even the touch of clothing on the affected skin (allodynia).
Itching and numbness. Less commonly, postherpetic neuralgia can produce an itchy feeling or numbness.

https://www.mayoclinic.org/diseases-conditions/postherpetic-neuralgia/symptoms-causes/syc-20376588