Tuesday, March 19, 2019 3:48:21 AM
o Tetracycline “Fluorocycline”
- C7 and C9 help avoid Tetracycline resistance
- Higher potency than tigecycline for GPC, GNR, anaerobes
o Indication: cIAI, not cUTI
o Susceptible pathogens: Gram positive, gram negative, anaerobes
o Warnings:
- Tooth discoloration, enamel hypoplasia
- Inhibition of bone growth
- CDI
o AE:
- Infusion site reactions, N/V
o Interactions
- CYP3A4
o Dosing 1mg/kg IV q12.
- Modified to q24h for severe hepatic impairment (after 24h @ q12h)
o Unique Aspects
- IV only
- Infusion site reactions and nausea
- High potency, reduced tetracycline resistance
- Option for ESBL
- Tetracycline warnings regarding pregnancy and fetal exposure
- Broad spectrum including anaerobes, MRSA, VRE.
o 34% to urine unchanged, 47% to feces unchanged
o Non-inferior to ertapenem in cIAI
o cUTI studies did not meet efficacy endpoints
BARRON'S COVE to Premier at the Hamptons International Film Festival • APHP • Sep 30, 2024 2:56 PM
Lingerie Fighting Championships Signs Broadcast Deal With Maybacks Global Entertainment • BOTY • Sep 26, 2024 9:00 AM
Maybacks Global Entertainment and Lingerie Fighting Championships Enter Into Broadcast And Revenue Sharing Agreement • AHRO • Sep 26, 2024 8:30 AM
North Bay Resources Commences Operations at Bishop Gold Mill, Inyo County, California; Engages Sabean Group Management Consulting • NBRI • Sep 25, 2024 9:15 AM
CEO David B. Dorwart Anticipates a Bright Future at Good Gaming Inc. Through His Most Recent Shareholder Update • GMER • Sep 25, 2024 8:30 AM
Cannabix Technologies and Omega Laboratories Inc. Advance Marijuana Breathalyzer Technology - Dr. Bruce Goldberger to Present at Society of Forensic Toxicologists Conference • BLOZF • Sep 24, 2024 8:50 AM