Monday, March 04, 2019 2:29:55 PM
I had to follow-up on you being a little suspicious that Spectrum did not release interim Z20 EGFRex20in pozi data like TGTX did with their interim data. Looking at TGTX news, I see a big reason why TGTX had no compunction in providing interim data to (what appears to be) a pivotal study is they needed to do a financing IMHO. They released the data, Share Price goes up 40%, and TGTX does their financing a couple of days later. The need for financing is a constant battle w biotechs. With over 300M in the bank (Spectrum announced the Completion of the Sale of its Marketed Portfolio on Fri), Spectrum can more conservatively wait for top line data later this year. It makes no difference to them since they won’t be doing any financing in the near future. So in their eyes, if the SP goes up now it would be nice but the bottom line is for the SP to go up closer to pozi news. And I’m expecting, with the earlier 1m scan, DoR and ORRs to go up in the Z20 study. From slide 9 in the Presentation, you can visually see that DoR would be about 1 month more and Dr Heymach said at WL that if they were using Z20 criteria of 1 m scans their RRs would be about 55%. And hopefully, a less reduced dosing schedule will also make a subtle difference. So, unless MDACC screwed up the interpretation of the scans in their study, I’m expecting very positive top-line, not interim results, later in the year. I always think of Dr Heymach’s response to a Q at WL 2017. Quoting/paraphrasing:
Ps I previously posted how I can see the agency reevaluating BTD but that’s something that no one can count on or expect but if it happens, they’d be getting it done the right way i.e. under the radar.
Recent SPPI News
- Form 15-12G - Securities registration termination [Section 12(g)] • Edgar (US Regulatory) • 11/09/2023 10:00:17 PM
- Form EFFECT - Notice of Effectiveness • Edgar (US Regulatory) • 09/28/2023 04:15:27 AM
- Form S-8 POS - Securities to be offered to employees in employee benefit plans, post-effective amendments • Edgar (US Regulatory) • 09/26/2023 09:23:08 PM
VHAI - Vocodia Partners with Leading Political Super PACs to Revolutionize Fundraising Efforts • VHAI • Sep 19, 2024 11:48 AM
Dear Cashmere Group Holding Co. AKA Swifty Global Signs Binding Letter of Intent to be Acquired by Signing Day Sports • DRCR • Sep 19, 2024 10:26 AM
HealthLynked Launches Virtual Urgent Care Through Partnership with Lyric Health. • HLYK • Sep 19, 2024 8:00 AM
Element79 Gold Corp. Appoints Kevin Arias as Advisor to the Board of Directors, Strengthening Strategic Leadership • ELMGF • Sep 18, 2024 10:29 AM
Mawson Finland Limited Further Expands the Known Mineralized Zones at Rajapalot: Palokas step-out drills 7 metres @ 9.1 g/t gold & 706 ppm cobalt • MFL • Sep 17, 2024 9:02 AM
PickleJar Announces Integration With OptCulture to Deliver Holistic Fan Experiences at Venue Point of Sale • PKLE • Sep 17, 2024 8:00 AM