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SIGNET MEDICAL SOLUTIONS, INC.

(A Subsidiary of Signet International Holdings, Inc. OTC: SIGN)

Signet Appoints M. Thomas Boyer Consultant
For the ConnREAP™, New Medical Device Prevents Amputations


Aurora, CO, February 26, 2019. Tom Donaldson, President of Signet International Holdings, Inc. (OTC:SIGN) announced today the appointment of M. Thomas Boyer, V/P, to assume a consulting role in the development of the new medical device, ConnREAP™. “I am pleased that Tom has accepted our offer to help us not only to characterize this incredible device, but to also represent Signet to medical academia. With more than 25 years as a health care leader, and after years of working with Dr. Conn, Tom is conversant with the ConnREAP™ procedure, including the business case and path to successful commercialization. We want to develop this patent and have it ready for market as soon as possible. We believe that Tom will help us achieve this,” says Mr. Donaldson.

The ConnREAP™ medical device, named for its inventor, Dr. John M. Conn, will be offered worldwide as a 5-piece disposable kit. The device will enable physicians—for the first time—to gain optimal access to the leg arteries and facilitate the best use of catheter and balloon equipment to restore blood flow and prevent amputations. According to independent studies, this device can substantially increase the rate of limb salvage. Tens of thousands of limbs could be saved annually in just the USA alone.

“I am very appreciative for the chance to join Signet’s effort and bring this innovation to market” said Boyer. “The ConnREAP device resolves a long-standing challenge of accessing blocked vessels below the knee. Dr. Conn’s invention gives surgeons a new tool to save limbs that are being amputated today. For patients suffering from Critical Leg Ischemia or other issues, the ConnREAP device can be THE tool that saves their leg.”

Colorado resident Mr. Boyer is a health care entrepreneur, former board member for a major hospital system, and the former board chair of one of the largest health care foundations in the United States.

“Our goal is to commercialize the ConnREAP device as quickly as possible,” says E. W. Letiziano, CEO, “the kits must be made available to all surgeons worldwide. In the past few years, we have experienced an upper trend of amputations over 180,000 in the US; imagine the whole world. This must stop. With the proper funding in place, we will drastically reduce this terrible number and make a difference; I hope those with a conscience will contact us. I had no idea this debilitating disease touches so many.”

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