Great stuff, coach. Unfortunately, my reading list just got much longer, lol.
One common thread I'm seeing in all of this research, including the BBB articles you comment on, is that a normal functioning human body has an incredible array of mechanisms/pathways to heal itself. Just focusing on the brain, there are mechanisms/pathways:
- to repair the blood-brain barrier (PDGF)
- to fight infections such as HSV
- to clear tau and amyloid-beta and toxins
- to repair synapse damage
- to protect neurons
- to repair damaged vasculature
The breakthrough discovery from Dr. Alkon's research is that pkc-e is the master switch for most of these pathways!
If pkc-e levels are normal, these pathways will work successfully to heal the body in most cases.
If pkc-e levels are low, these pathways are less successful at healing the body, and over time, the components of the brain are overwhelmed. If the BBB is damaged, pathogens and toxins make their way into the brain, potentially overwhelming it's ability to fight pathogens and toxins.
Immunological responses to these pathogens/toxins results in an increase in tau/a-beta. If the brain is overwhelmed and can't successfully clear tau/a-beta, they eventually cleave to the synapses (a-beta) or are found in neurons. The synaptic network is damaged, memory fails, and over time the brain works less and less effectively.
I think the multi-modal aspect of PKC-e is what will distinguish us from all other approaches/drugs, since PKC-e is involved in most pathways that are involved in brain health.
Research suggests there may be many causes of Alzheimer's disease, such as genetic or dietary or environmental or brain trauma or BBB damage or infection or toxins, all of which eventually leads to synapse damage and loss. Through it's effect on multiple pathways, PKC-e fixes damaged BBB. PKC-e clears out tau/a-beta. PKC-e repairs damaged synapses. PKC-e protects neurons. PKC-e repairs vascular damage. PKC-e compensates for genetic defects such as apoe4.
And because we influence so many pathways, we will be able to treat many diseases, unlike most of the other treatments that work on only one cause of one disease. The importance of this will become clearer as the competition catches up. Especially if synthetic Brystatin is relatively inexpensive to manufacture and we prove we can reverse all of the brain damage listed above.
In reading all of these articles, it’s easy to get lost in the maze of symptoms and treatments, and forget all the amazing properties of PKC-e, triggered by Bryostatin.
Thanks for highlighting yet another pathway (PDGF) that Bryostatin will help by targeting PKC-e!
AI
