One can see that this clinical failure is significant from an investment standpoint by turning the result on its head: i.e., if the trial in question had succeeded, it would surely have caused a material bump in ABBV’s (and even JNJ’s) valuation. So, the absence of such a bump is itself a notable event. I disagree, you can't stand it on its head because it's asymmetric. Failure = expected. Positive result = wildly unexpected. When a drug is tested in multiple solid tumor types, pancreatic is always the first to report and is always a failure. I don't think failure of any drug in pancreatic says anything about its efficacy in other tumor types.