Spectrum Pharmaceutecals Inc (SPPI)

[Tartiaboy]

The way I read the graphs is that there were 12 responders.

Only 7 responders were available for DOR, the other 5 were censored.

Six of the seven measured responders had DOR > 6 months.

However since there were 12 initial responders they had to use that as the denominator: i.e. 50% of the responder were over 6 months.

I look at the data for prediction purposes, not for stringent filing purposes.

So. If only 7 patients were available for actual DOR and 6 were over six months, I extrapolate that to the Zenith trial and predict that most of the responders will be available for DOR analysis (few censored) and that 85% will be over 6 months. Also some of the responders had not had an event at filing time. That's why I expect a DOR of 8+ months. 9 or 10 months won't surprise me.