BioPharmX Corp fka BPMX

[Whos_Who]

BioPharmX VS the Competition

* Dermatologists and their sufferers want a greater method

* A perfect answer may be a brand new topical antibiotic formulation

* A number of corporations have unsuccessfully tried to develop business topical or transdermal supply methods for minocycline for the US market. For years, researchers have been unable to stabilize minocycline in a supply system that may penetrate the stratum corneum, the outer layer of the dermis.

* The BioPharmX gel supply system guarantees to be a cosmetically elegant answer. The gel absolutely solubilizes minocycline and leaves no hint of the antibiotic on the pores and skin. It additionally leaves no oily residue on the pores and skin which will discourage affected person compliance. The BioPharmX BPX-01 topical minocycline gel formulation for pimples additionally evaporates, which will increase the floor focus gradient to improve supply of the API into the pores and skin and may soothe and funky the pores and skin. Medical analysis on BPX-01, a 2% minocycline focus, discovered the treatment was properly tolerated with an excellent security profile and was nearly undetectable in blood plasma.17 In consequence, no systemic negative effects are anticipated.

* The Foamix foam suspends minocycline and leaves residue on the pores and skin which will irritate the pores and skin and stain garments and bedding.21 Whereas researchers detected minocycline in the pilosebaceous unit, together with the hair follicle and the sebaceous gland, it isn’t clear whether or not the lipid-based mostly foams will clog pores, one thing that could be worrisome for pimples sufferers and their clinicians.

* The two corporations use totally different concentrations of minocycline in their merchandise. BioPharmX makes use of 2% solubilized minocycline in BPX-01 gel, whereas Foamix makes use of double the focus – or Four% minocycline

Foamix focus could also be wanted for a number of causes. In its formulation, the minocycline shouldn’t be dissolved, it’s suspended in the foam. This may increasingly make it harder for the minocycline to penetrate into the pilosebaceous unit, towards the move of sebum. Accordingly, the foam car stays on the pores and skin to assist penetration, however with extra drug, which can irritate the pores and skin and clog pores.

One factor is for certain – the dermatologic group is anxiously awaiting a topical antibiotic corresponding to minocycline.

Jan. 11, 2019
https://www.google.com/amp/s/sildenafilmedsusa.com/topical-delivery-novel-approaches-to-topical-antibiotics-promise-innovation-in-the-treatment-of-acne-rosacea/amp/