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Re: misiu143 post# 33699

Thursday, 01/17/2019 8:08:29 AM

Thursday, January 17, 2019 8:08:29 AM

Post# of 233066
Good response - my comments and questions

While PD-1 and PD-L1 inhibitors work on breaking the bond, their direction and place of action is different and as such PD1 inhibitors are more effective and Ketruda is really leading.

PD1 inhibitors unleash T cells by taking off checks which allow to identify cancer cells and kill them. So they are more effective but also have more side effects

PDL1 inhibitors act on cancer cells and expose them but do not unleash T cells so they are less effective at least currently

Question - where CCR5 fit into this MOA and how it is supposed to enhance the PD1 results?
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