Wednesday, January 16, 2019 4:21:44 PM
Your last comments get to the train of thought that I'm working through. Studies are currently being done using Keytruda and CCR5 inhibitors (maraviroc, in particular). Preclinical data from circa 2012 suggests that this is likely to be effective, but Merck doesn't have the IP to use maraviroc (commercially) to inhibit cancer metastasis. That makes Merck an obvious candidate for partnership, etc. However, Eli Lilly just bought LOXO (and Vitrakvi), and has indicated an interest in continuing to expand its oncology program but doesn't like the CAR-T approach. It apparently wants some diversity and broad usefulness in its assets. I'm wondering if CCR5 inhibitors would pair well with Vitrakvi, or other drugs in the LOXO pipeline, which would potentially make EL another player on our little stage.
https://www.reuters.com/article/us-lilly-cancer/lilly-eyes-more-cancer-deals-but-wary-of-car-t-gene-therapy-idUSKCN1P5294
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