Some people know how to play them. Ronnie, for example, gives me grief for going with the big popular plays. He's a master at the low float stocks, and he says they make him money.
You have to get in at the very bottom, and you have to know how to trade your way out of your position. You need to sell small amounts at the ask, and just wait for the buyers to come to you. You CANNOT sell at the market, or drop your whole investment on the bid. The MMs will step out of the way, and collapse the bid to 30% below where it had been a moment ago.
Low float, low volume stocks demand a level of patience which I don't usually have, unfortunately. I know I should develop some. Yeah..someday.
_______________________________________________________
If you take anything I say as advice, you're crazier than I am.