SiNtx Technologies Inc (SINT)

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Bone vasculature plays a vital role in bone development, remodeling and homeostasis. New blood vessel formation is crucial during both primary bone development as well as fracture repair in adults. Both bone repair and bone remodeling involve the activation and complex interaction between angiogenic and osteogenic pathways. Interestingly studies have demonstrated that angiogenesis precedes the onset of osteogenesis. Indeed reduced or inadequate blood flow has been linked to impaired fracture healing and old age related low bone mass disorders such as osteoporosis. Similarly the slow penetration of host blood vessels in large engineered bone tissue grafts has been cited as one of the major hurdle still impeding current bone construction engineering strategies.

RediHeal Wound Care is a borate-based biological glass that contains trace elements to promote a strong angiogenic response

Copper promotion of angiogenesis has been known for more than two decades, but the mechanism of action of copper has not been explored until recently.

https://www.ncbi.nlm.nih.gov/pubmed/19355887

At least 12 enzymes exist in the body that doctors call “cuproenzymes.” These are dependent on copper to function

Copper toxicity, also called copperiedus, is a type of metal poisoning caused by an excess of copper in the body

This is when you`re leaps ahead of the competition and your own research has to battle itself. FITE!

So, does SiNi promote angiogenesis? How much copper promotes angiogenesis compared to the amount you need to cause metal poisoning vs. obtaining it's antibacterial effect? My guess: if you got a blood infection just eat a bunch of copper; said no one ever. My guess is it's broadly cytotoxic at the levels needed for an antibacterial effect in vivo. I could be wrong here.

What if we can have the best of both worlds? Provided SiNi has nothing to do with angiogenesis. A silicon nitride, with all the benefits of silicon nitride with increased angiogenesis?

Therefore, one of the challenge in tissue engineering is to
develop bioactive glass scaffolds that can be processed with
a controlled degradation and with a full conversion into a
calcium phosphate reactive layer that will enable cell adhesion, proliferation and differentiation. The scaffold should have mechanical properties close to the tissue to be replaced while having porosity adequate for cell migration and angiogenesis. It is unlikely that one material alone will solve this engineering challenge

Sounds like SiNi coated copper doped, Calcium doped, Borosilicate bioglass could out perform SiNi when bio bioresorbable is considered desirable? But what if we're wrong? what if, when looking for bioresorbable we change that to partially bioresorbable with SiNi to create a fully incorporated healed bone scaffold stronger than the original?

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You bring up a good point. Now that we know galvanic corrosion of dissimilar metals exists Whats the interplay between Metal oxide ceramics in contact with metal stems? IE what does galvanic corrosion mean when dealing with metals in their oxidized ceramicized form?

Like corrosion particulate vs wear particulate in chrome cobalt heads. Hanging out near a copper processing facility; is the raw metal the issue or things like copper sulfate pentahydrate. Highly soluble in water. I`m guessing this means better bioavailability. Similar to the dangers posed between lead oxide vs. solid lead.