Thursday, December 27, 2018 5:39:56 PM
The financing situation sucks I'm not gonna sugarcoat it, but eventually something is going to give either an offer for a buyout or a licensing deal. Is it taking a lot longer than expected? Yes, but long-term I think leronlimab is a potential blockbuster drug.
I will give you an example. Look at HUMIRA it started off as a typical human monoclonal antibody for Rheumatoid arthritis(RA). RA is an immunological disorder. HUMIRA stands for HU - Human M- monoclonal Iga antibody Rheumatoid arthritis. The point being is that it started off as only treating one indication and now treats multiple indications. It has ended up being worth a $15 billion a year drug.
What's my prediction? Well, pro-140 is also a monoclonal antibody granted it targets CCR5 instead of HUMIRA which targets TNF - tumor necrosis factor instead. The point is that if pro-140 can be adapted to cancer, multiple scelorisis, GVHD, HIV, and other indications then it too can eventually become a billion dollar blockbuster like Humira. Leronlimab has shown strong efficacy in HIV monotherapy with a 92% response rate which is very strong for a single agent. Other HIV drugs have to use 2 to 3 agents combined. The point being is that for Pro-140 not only may it be able to treat all these diseases but it may be a monoclonal antibody that severely avoids the side effects associated with other monoclonal antibodies.
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